The development of Regenerative Rehabilitation approaches to optimize tissue regeneration and repair has the potential to enhance the efficiency of rehabilitation interventions for a host of injuries and diseases.

To accelerate scientific progress in this emerging field and to minimize disciplinary barriers, AR3T has assembled a multi-institutional network of laboratories that are conducting state-of-the-art research in the domains of stem cell biology, biomarkers, tissue plasticity and regeneration, and regenerative medicine therapeutics. This network will offer a broad range of consultative services intended to enrich the research capacity of the medical rehabilitation research community across three core areas.

Alliance for Regenerative Rehabilitation Research & Training

Core 1: Cellular Therapeutics/Tissue Engineering

Drs. Thomas Rando and Carmen Terzic will serve as directors of the Cellular Therapies/Tissue Engineering Core. This Core will offer expertise and training in stem cell isolation, expansion, differentiation and characterization; the generation of induced pluripotent stem cells; protocols for genetic modification of precursor cells; protocols for the design and testing of tissue engineering protocols including scaffold design and implantation; and regulatory assistance and advice concerning clinical translation.

Core 2: Mechanotransductive Methods

Drs. Fabrisia Ambrosio and Linda Noble-Haeusslein will serve as directors of the Mechanotransductive Methods Core. This Core will offer expertise in vitro and in vivo methods to manipulate and measure cellular and tissue responses to mechanical loading and biophysical stimuli, as well as protocols for administering functional outcomes testing including in situ contractile testing, kinematic analysis, biomechanical testing of tendon and bone, and a suite of tests for assessing behavior in rodent models.

Core 3: Rehabilitation & Mechanosensitive Biomarkers

Dr. Gwendolyn Sowa will serve as director of the Mechanosensitive Biomarkers Core. This Core, comprised of rehabilitation clinicians, biochemists, molecular biologists, bioengineers will provide expertise to facilitate development of new model systems and will supply the unique resource of biomarker identification to facilitate titration of treatments for optimal biologic outcomes. These resources, coupled with rich experience in examining peripheral (blood and urine) based biomarkers in response to treatments and as predictors to outcomes, will provide the ability to fully translate our basic science knowledge of the benefits of regenerative rehabilitation to the clinic.

Visit menu items to learn more about collaboration opportunities within the AR3T cores.