Workshops will be held immediately after the Symposium on Regenerative Rehabilitation, November 3, 2017, from 12:30-2:30. Lunch will be provided. Join us for one of two focus areas, presented by experts in the fields - Clinical Research for Regenerative Rehabilitation or Rehabilitation Strategies in Preclinical Models: An Overview of the Fundamentals.
Pre-registration (coming soon) is required.
Please see the Learn More page for fee information.
Clinical Study Design for Regenerative Rehabilitation Researchers
The goal of this workshop is to address challenges and current opportunities specific to clinical trials in medical rehabilitation, including: trial design, issues in recruitment and retention, funding opportunities, and mobile technology integration into rehab trials. We will introduce investigators to the REACT Center course offerings and additional resources, including the Scholar Award and Pilot Award Programs, and to the MR3 Network Coordinating Center.
Following an introductory lecture, workshop participants will divide into breakout sessions based on their experience level as investigators:
Researchers at all levels of training/expertise who are interested in clinical trials are welcome to attend.
The sessions will be led by Dr. Bamman, along with Dr. Gary Cutter, Co-Director, REACT and professor of biostatistics in the Section on Research Methods and Clinical Trials in the Department of Biostatistics at the UAB School of Public Health; and Dr. Robert Motl, REACT Mobile Technology Lab Director, Associate Director for Rehabilitation Research at the UAB Center for Exercise Medicine, and professor in the UAB Department of Physical Therapy.
Biosketch: Marcas Bamman, PhD, FACSM:
Professor, Department of Cell, Developmental, and Integrative Biology
Director, UAB Center for Exercise Medicine
Director, P2CHD086851 National Rehabilitation Research Resource to Enhance Clinical Trials (REACT)
Director, T32HD071866 Interdisciplinary Training in Pathobiology and Rehabilitation Medicine
Exercise profoundly impacts the integrity and function of every major organ system, and is therefore considered the only pluripotent form of medicine available. To maximize impact on disease progression, prevention (i.e. risk factor mitigation), and rehabilitation, the state-of-the-art in research is a focus on dose-response trials to provide the evidence base that yields optimal prescriptions in a disease-specific and population-specific manner. The UAB Center for Exercise Medicine is among the nation’s leaders in this effort, with significant emphasis on exercise as an effective form of regenerative medicine to restore the function of cells, tissues, and whole organ systems that have suffered the consequences of aging, disease, damage, or congenital defects. The Center is currently leading clinical and translational research in aging, Parkinson’s disease, multiple sclerosis, ALS, spinal cord injury, epilepsy, head and neck cancer, heart failure, osteoarthritis, HIV frailty, and post-surgical rehabilitation (i.e. following total joint replacement and organ transplantation).
Over the years Dr. Bamman has directed several exercise clinical trials including randomized dose-response trials focused on aging (e.g., NIH 5R01AG017896, NCT02442479), and he is currently the overall Principal Investigator (PI) or site PI of five, multi-site randomized exercise trials focused on: (i) molecular transducers of exercise-induced health benefits (NIH Common Fund MoTrPAC trial, U01AR071133); total joint arthroplasty rehabilitation (NIH R01HD084124, NCT02628795); (ii) aging with mobility impairment (NIH R01AG046920, NCT02308228); (iii) Parkinson’s disease (Curry Foundation); and (iv) epigenetic determinants of exercise responsiveness (Department of Defense MURI trial). All of his human studies are biologically driven – centered on cellular/ molecular analyses of biospecimens and primary stem cells coupled with thorough in vivo phenotyping in healthy (19 to 83 y/o) and diseased – to better understand mechanisms of exercise-induced improvements in neuromuscular function and muscle mass/quality in the face of atrophy and dysfunction in acute (e.g., surgery, trauma, disuse, burn) or chronic (e.g., Parkinson’s, arthritis, cancer, spinal cord injury) conditions. Dr. Bamman has served on >35 federal review panels and NIH study sections, including a 4-year term serving the NIH/CSR Skeletal Muscle and Exercise Physiology (SMEP) study section.
Rehabilitation Strategies in Preclinical Models: An Overview of the Fundamentals
Regenerative Rehabilitation reflects the intersection between two fields of expertise- namely regenerative medicine and rehabilitation science. Assuming the viewpoint of the benchtop researcher, we will first focus on those key elements of rehabilitation that are complimentary to regenerative medicine; namely, defined methods of exercise in rodent models. We will consider optimizing the experimental design, aimed at reducing bias and improving transparency; and the pros and cons of different rehabilitation methods such as wheel running, treadmill running and electrical stimulation. Lastly, we will review behavioral outcomes that are designed to measure motor/sensory function and cognition, parameters that are sensitive to transplantation, endogenous stem cell behavior, and exercise.
Treadmills and wheel running (forced or voluntary)
Behavioral outcome measures
Cognitive- learning, memory, fear, anxiety
Motor/sensory- CatWalk/Digigait, rotorod, open field test
Researchers at all levels of training/expertise who are interested in learning about rehabilitation and behavioral testing in rodent models of injury and disease.
Dr. Linda Noble-Haeusslein (UCSF and UT Austin Dell Medical School)
My laboratory has incorporated measures of motor/sensory function and cognition into preclinical models of spinal cord injury and traumatic brain injury for well over 2 decades, with the objective of identifying targets that are early determinants of long-term recovery. This collective research has led to the development of a battery of behavioral tests that can be used to assess functionality following stem cell transplantation and/or other approaches aimed at supporting endogenous stem cells. As a former founder and co-director of the neurobehavioral core at UCSF, I am also familiar with rodent-based exercise interventions that incorporate defined activity to restore motor/sensory function and cognition.
Dr. Gordon Warren is a Distinguished University Professor in the Department of Physical Therapy at Georgia State University in Atlanta, Georgia. He has conducted research on skeletal muscle injury and combined muscle-bone injury for 27 years. He has conducted this research using both humans and animals. In his animal research, he has implemented single fiber models as well as in vitro, in situ, and in vivo muscle models in the induction of muscle injury as well as in the assessment of the muscle’s functional capacities. He also has experience using modalities to increase or decrease muscle activity (e.g., treadmill running, use of running wheels, restricted cage activity) so as to examine its effect on muscle’s recovery from injury.
The 6th Annual Symposium on Regenerative Rehabilitation is supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institute Of Arthritis And Musculoskeletal And Skin Diseases (NIAMS), and National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health under award number R13HD085724. The content of this website is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.