Workshops will be held immediately after the Symposium on Regenerative Rehabilitation, November 3, 2017, from 12:30-2:30. Lunch will be provided. Join us for one of two focus areas, presented by experts in the fields - Clinical Research for Regenerative Rehabilitation or Rehabilitation Strategies in Preclinical Models: An Overview of the Fundamentals.

Pre-registration is required. For more information about workshops, please contact ar3t@pitt.edu.

Clinical Study Design for Regenerative Rehabilitation Researchers

Workshop Abstract

The goal of this workshop is to address challenges and current opportunities specific to clinical trials in medical rehabilitation, including: trial design, issues in recruitment and retention, funding opportunities, and mobile technology integration into rehabilitation trials. We will also introduce investigators to the REACT Center course offerings and additional resources, including the Scholar Award and Pilot Award Programs, and to the Medical Rehabilitation Research Resource (MR3) Network Coordinating Center.

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Rehabilitation Strategies in Preclinical Models: An Overview of the Fundamentals

Workshop Abstract

Creating synergies through the integration of regenerative medicine and rehabilitation in preclinical models will result in research that can be translated into the clinic, with the ultimate goal of optimizing independence and participation of individuals with disabilities.
Regenerative Rehabilitation reflects the intersection between these two fields of expertise- regenerative medicine and rehabilitation science. Assuming the viewpoint of the benchtop researcher in this workshop, we will focus on those key elements of rehabilitation that are complimentary to regenerative medicine; namely, defined methods of exercise in rodent models and outcome measurements for evaluation. We will start out by discussing optimization of the experimental design, reducing bias and improving transparency when using rodents for behavioral research. We will then review the pros and cons of different rehabilitation methods such as wheel running and treadmill running. Two animal models of cutting-edge regenerative medicine research will be described in detail as examples- traumatic muscle injury (specifically volumetric muscle loss) and traumatic brain injury, although the rehabilitative methods and evaluation techniques for these models are useful across a broad range of preclinical models of regenerative medicine research. Lastly, we will review behavioral outcomes that are designed to measure motor/sensory function and cognition, as well as methods for assessing muscle strength, parameters that are sensitive to transplantation, endogenous stem cell behavior, and exercise.

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